New Gout Therapies Show Promise in Phase III Trials tammytilley@gm… Sun, 10/26/2025 – 16:06

Upadacitinib in GCA doesn’t just affect IL-6, it alters IFNg, known to be important in vascular change in GCA. If

A closer look in skin toxicity of GCs in RMDs GC Toxicity Index, LONG TOX prospective cohort Frequent: -Easy bruising

Nice SRMA evaluating HCQ dosing >5mg/kg associated w/3.8x risk of retinopathy… …but <5mg/kg associated w/1.8 https://pbs.twimg.com/profile_images/1982460526815764480/EQEuBdmh_normal.jpg john+RNV2@john… Sun, 10/26/2025 –

PD-1+ effector memory T cells in PsA synovium are functionally active and regulate Th17 cytokines via STAT3/RORγt. Reco https://pbs.twimg.com/profile_images/926606033270665216/Z42VohYE_normal.jpg john+RNV2@john…

What is #nonadherence in #SLE associated with? 115 Pts w #lupus in Spain Overall medication adherence 58%! 👇Reduce https://pbs.twimg.com/profile_images/1007774150000332801/SjLeJk3G_normal.jpg john+RNV2@john…

Two Jacks, One mission 🤓 Head on to the booth and get a chance to meet either one of them

CE study BEL vs csDMARDs in TriNetX Mortality ~3-4% for MTX/AZA/MMF vs ~1.5% for BEL, ~50% reduction in adjusted analys

#ACR25 Abstr#802 In #SLE pts with CLASI-A ≥8, pooled post-hoc analysis of Phase 2 RCT showed enpatoran, oral small mol

Urinary proteomics reveals promising biomarkers for ankylosing spondylitis. PIK3IP1 & SDC1 levels were significantly https://pbs.twimg.com/profile_images/926606033270665216/Z42VohYE_normal.jpg john+RNV2@john… Sun, 10/26/2025 – 15:01

Effect of BioDMARDs on Diabetes risk in 6400+ Psoriasis pts IL-23i and IL-17Ai associated w/ -lower risks of diabetes https://pbs.twimg.com/profile_images/1800478984926334976/yyyPLP4A_normal.jpg

Avacopan in the real world: we need to be braver If we want to get steroid-sparing benefit in AAV, we

Can the blood reflect what’s happening in the joint? In early RA, 11 synovial proteins mirrored serum levels, forming https://pbs.twimg.com/profile_images/1525262133575012354/Lfut18gD_normal.jpg

A systematic review by Dr. SRamiro et al evaluated efficacy of b/tsDMARDs on peripheral axSpA Majority on bDMARDs (TNFi https://pbs.twimg.com/profile_images/1027501556868870145/2culK0bN_normal.jpg

Cool study using vasculitis patient-powered reserach network (VPPRN) “SNOT-22” tool captures sinonasal symptoms; associ https://pbs.twimg.com/profile_images/1982460526815764480/EQEuBdmh_normal.jpg john+RNV2@john… Sun, 10/26/2025 – 12:54

Miller et al. Fibrinogen for GCA diagnosis and flare identification. Similar to ESR/CRP in diagnosis. For flares, lower https://pbs.twimg.com/profile_images/1389468430160510976/sooz0Ud3_normal.jpg john+RNV2@john…

ASAS recommends standardised reporting for 20 key outcomes in axSpA trials, 10 for all studies, 10 specific to DMARD tri

Poster evaluating representation in trials of AAV and GCA Results mirror those observed in other fields; need to keep a

#ACR25 Abstr#776 2-Year SELECT-GCA RCT showed that #GCA patients receiving continuous UPA15 to 2-yr maintained their rem https://pbs.twimg.com/profile_images/1625445768768135171/M24lCgC__normal.jpg john+RNV2@john… Sun,

Fascinating: tDR-1, a microbial sRNA, appears protective for RA in at risk ACPA+ pts: – tDR-1 higher = less develop

No seasonal pattern in GCA! We have also looked at this in our data and similarly found no trends It

Rheumatoid arthritis and the ‘big bang’ at the ACR! Janet.Pope@sjh… Sun, 10/26/2025 – 12:15

#0191 We found that in a large South London RA cohort, use of advanced therapy in moderate disease (DAS28 3.2-5.1)