RheumNow

Saphnelo (anifrolumab) has been recommended for approval in EU by CHMP for systemic lupus erythematosus (on top of stand https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg […]

12 yr study of 115 Systemic Sclerosis pts shows Finger-to-palm distance (tip 4th finger to distal palmar crease) may be

UK National Joint Registry study of 1.5 million TKR and THA (2010 to 2022); trends show median Length of hosp

Phase 3b/4 head-to-head SELECT-SWITCH study tested Humira vs Rinvoq in 492 RA MTX pts failing a TNFi then Rx w/

Colchicine Ineffective in Long COVID jjcush@gmail.com Tue, 10/21/2025 – 14:20

Study from Czech ATTRA registry of 8,543 RA pts 641 (7.5%) met criteria for D2T-RA & 1,825 achieved remission (21%).

30% of RA pts have non-alcoholic fatty liver disease (NAFLD). In 170 pts on MTX or biologics (TNFi, IL-6i)- NAFLD

Bad Actor Cofactor (10.17.2025) Dr. Jack Cush reviews the news and journal reports, discusses pediatric reports, pregn https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg john+RNV2@john… Tue,

SGLT-2 inhibitors and the prevention of autoimmune rheumatic disease jjcush@gmail.com Tue, 10/21/2025 – 08:00

SGLT-2 inhibitors for the prevention of autoimmune rheumatic diseases jjcush@gmail.com Tue, 10/21/2025 – 00:31

Telitacicept Effective in Systemic Lupus Erythematosus The NEJM has published a report from van Vollenhoven et al show https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg john+RNV2@john…

SAIL-RA: Finding ILD in Early RA Cohort study of early rheumatoid arthritis (RA) patients finds that interstitial lung https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg john+RNV2@john…

FDA Approves Obinutuzumab for Active Lupus Nephritis jjcush@gmail.com Mon, 10/20/2025 – 18:17

FDA has approved Genentech’s CD20-targeting antibody obinutuzumab (Gazyva) for the treatment of adult patients with lu https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg john+RNV2@john… Mon, 10/20/2025

Retrospective study of 423 seropositiv RA pts (SPRA) finds 21% with baseline ILD; over 10 yrs 31% had ILD. High

Interleukin-18 (IL-18) regulates appetite, body weight & glucose homeostasis. IL-18 deficiency may lead to obesity, https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg john+RNV2@john… Mon, 10/20/2025 –

Study of biopsy proven lupus nephritis pts (1970-2024) – a total of 324 LN pts followed for median 9.9 yrs —

“Never in the field of human conflict was so much owed by so many to so few.” – Winston Churchill

Skin Biopsies to Predict Scleroderma Outcomes? Researchers from the Hospital for Special Surgery and Weill Cornell Med https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg john+RNV2@john… Fri,

Metanalysis of whole-body cryotherapy (WBC) in Ankylosing spondylitis (AS) – 5 studies & 310 #AS pts. Temps (−60° https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg john+RNV2@john…

CONGRATULATIONS: Dr. Lauren Henderson has been awarded the Gale & Ira Drukier Prize in Children’s Health Research https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg john+RNV2@john… Fri,

JAMA Pediatrics study of 1,473 young US adult, finds 1/4 use cannabis or alcohol for sleep (18% cannabis; 7% EtOH),

A high ANA titer (≥1:640) in individuals without an autoimmune disease was found to be strongly associated with liver- https://pbs.twimg.com/profile_images/1113146320812937216/PnWu5uSX_normal.jpg

Arthritis Pain and Education Gaps Linked Save New research from The University of Texas at Arlington shows that differe https://pbs.twimg.com/profile_images/1915149062988271616/2m4z_QPt_normal.jpg

Failure of IL-17 inhibition in Lupus nephritis. 31 LN pts enrolled in phase 2 DBRPCT of secukinumab 300 mg IV,

Bad Actor Cofactor (10.17.2025) jjcush@gmail.com Fri, 10/17/2025 – 00:46 Education/ACR/EULAR Anti-Rheumatic Rx AS/Spondyloarthritis Drug Safety Fibromyalgia/Pain JAK/TYK2 Lupus Novel Rx