NEJM

A 5-year-old boy was admitted to the hospital because of fever and rash. Nonblanching papules spread from the feet to […]

This review summarizes the diagnosis and treatment of complex regional pain syndrome, a rare limb-pain disorder. Early rehabilitation and multidisciplinary

This trial of pegcetacoplan, a C3 and C3b inhibitor, in patients with C3 glomerulopathy or primary immune-complex membranoproliferative glomerulonephritis showed

The kidney diseases C3 glomerulopathy and immune-complex membranoproliferative glomerulonephritis (MPGN), which are diagnosed through kidney biopsies in patients with evidence

This review updates the pathophysiology and disease course of acromegaly, focusing on the general clinician’s key role in early diagnosis

Approximately 5 million persons in the United States have psoriasis.1 Most have mild disease covering less than 3% of body-surface

Opioid deprescribing is advised when risks of opioid use outweigh benefits. A tailored, patient-centered plan with gradual dose reduction, monitoring,

In moderate-to-severe plaque psoriasis, oral icotrokinra led to a skin-clearance response in 50 to 65% of patients at week 16,

In this randomized trial, reduction in knee pain at 3 months was similar in participants assigned to home exercise alone

Teclistamab, a T-cell engager targeting B-cell maturation antigen, showed promise as a rescue therapy in 10 patients with refractory autoimmune

In a trial involving participants with systemic lupus erythematosus, the incidence of a clinical response was higher with telitacicept than

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles

A 5-year-old boy with IgA vasculitis presented with scrotal swelling and pain and worsening of his leg rash. The physical

A 71-year-old woman with systemic lupus erythematosus presented to the ophthalmology clinic for an annual screening examination for hydroxychloroquine-related toxic

A 26-year-old man who had emigrated from Nepal 7 years earlier presented with ankle swelling, cough, unintentional weight loss, and

Sarcoidosis, a granulomatous disease that affects the lungs and other organs, has a variable course. Although spontaneous resolution of sarcoidosis

In this randomized trial, first-line treatment of pulmonary sarcoidosis with methotrexate was noninferior to that with prednisone regarding the change

This review discusses the features of oligoarticular, polyarticular, systemic, and psoriatic JIA and enthesitis-related arthritis, as well as advances in

A 57-year-old man presented with a 2-week history of worsening shortness of breath. Radiography and CT showed perihilar airspace opacities

A 63-year-old woman was evaluated for dyspnea and edema. Soft-tissue thickening was noted in the retroperitoneum and mediastinum and around

Myasthenia gravis, an immune-mediated neurologic disorder, has for the past century been treated effectively with various immunotherapies, ranging from thymectomy

Intracranial aneurysms are common, and the risk of rupture is influenced by size, location, morphology, and factors such as hypertension,

In adults with myasthenia gravis, treatment with intravenous inebilizumab, a CD19-specific monoclonal antibody, significantly improved function and reduced disease severity

A 34-year-old man was admitted to the hospital because of left ear pain with hearing loss and facial droop on

The field of pulmonary fibrosis has come a long way in the past 25 years, with the approach to patient

In this randomized, placebo-controlled trial involving patients with giant-cell arteritis, the oral Janus kinase inhibitor upadacitinib (15 mg) significantly improved