Realignment Surgery Definitely Helps in Knee OA, Trial Indicates
(MedPage Today) — Surgically reshaping the tibial bone to correct misalignment in the knee joint helped preserve cartilage and improved […]
Nature Reviews Rheumatology
Dynamic macrophage phenotypes in autoimmune and inflammatory rheumatic diseases
Nature Reviews Rheumatology, Published online: 28 July 2025; doi:10.1038/s41584-025-01279-w Phenotypic and functional plasticity of macrophages is implicated in the pathophysiology
Got Patients With Refractory axSpA or PsA? Consider This Option
(MedPage Today) — Although most patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) didn’t respond adequately to the interleukin-17
Nature Reviews Rheumatology
Timing matters in diagnosis of cancer with immune-mediated inflammatory disease
Nature Reviews Rheumatology, Published online: 24 July 2025; doi:10.1038/s41584-025-01288-9 Immune-mediated inflammatory diseases (IMIDs) are associated with cancer risk through mechanisms
NEJM
Hydroxychloroquine Retinal Toxicity
A 71-year-old woman with systemic lupus erythematosus presented to the ophthalmology clinic for an annual screening examination for hydroxychloroquine-related toxic
NEJM
Löfgren’s Syndrome
A 26-year-old man who had emigrated from Nepal 7 years earlier presented with ankle swelling, cough, unintentional weight loss, and
Yes, HCQ Does Help Preserve Renal Function in Lupus Nephritis
(MedPage Today) — Lupus nephritis (LN) patients on long-term therapy with hydroxychloroquine (HCQ) showed significantly less decline in renal function,
Rheumato
Rheumato, Vol. 5, Pages 9: Adipokines: Do They Affect the Osteochondral Unit?
Rheumato, Vol. 5, Pages 9: Adipokines: Do They Affect the Osteochondral Unit? Rheumato doi: 10.3390/rheumato5030009 Authors: Sergio Rosini Gianantonio Saviola
Nature Reviews Rheumatology
Addressing the challenge of global delays in diagnosis and treatment of systemic lupus erythematosus
Nature Reviews Rheumatology, Published online: 21 July 2025; doi:10.1038/s41584-025-01277-y Delays in the diagnosis of systemic lupus erythematosus negatively affect the
Farm Women With Rheumatoid Arthritis: Are Pesticides to Blame?
(MedPage Today) — Women exposed to pesticides through farm work or as farmers’ wives face increased risk for developing rheumatoid
NEJM
Methotrexate as Initial Therapy for Symptomatic Pulmonary Sarcoidosis?
Sarcoidosis, a granulomatous disease that affects the lungs and other organs, has a variable course. Although spontaneous resolution of sarcoidosis
NEJM
First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate
In this randomized trial, first-line treatment of pulmonary sarcoidosis with methotrexate was noninferior to that with prednisone regarding the change
This Drug May Safely Treat Psoriasis Exacerbations From Cancer Therapy
(MedPage Today) — Psoriasis flares that came on as a result of immune checkpoint inhibitor (ICI) therapy for cancer were
NEJM
Juvenile Idiopathic Arthritis
This review discusses the features of oligoarticular, polyarticular, systemic, and psoriatic JIA and enthesitis-related arthritis, as well as advances in
Could Your Morning Granola Cut Gout Risk?
(MedPage Today) — People who like to eat whole-grain cereals rich in certain phytoestrogens had significantly lower risk for developing
Study: Yes, Psoriasis Progression to PsA Can Be Stopped
(MedPage Today) — Tumor necrosis factor (TNF) inhibitor therapy was effective in reducing the likelihood that psoriasis would progress to
NEJM
Diffuse Alveolar Hemorrhage in ANCA-Associated Vasculitis
A 57-year-old man presented with a 2-week history of worsening shortness of breath. Radiography and CT showed perihilar airspace opacities
Certain Autoimmune Skin Diseases Linked to Better Cancer Prognosis
(MedPage Today) — Individuals with pre-existing autoimmune skin diseases (ASDs) had disproportionately better survival outcomes after antineoplastic treatment for cancer,
CMS to Test Prior Authorization Model in Traditional Medicare
(MedPage Today) — The Centers for Medicare & Medicaid Services (CMS) announced a new experimental model late last week to
JAK Inhibitors’ Cancer Risk Confirmed in Real-World Data
(MedPage Today) — Use of Janus kinase (JAK) inhibitors for rheumatoid arthritis (RA) was associated with significantly higher rates of
NEJM
Case 18-2025: A 63-Year-Old Woman with Dyspnea on Exertion
A 63-year-old woman was evaluated for dyspnea and edema. Soft-tissue thickening was noted in the retroperitoneum and mediastinum and around
Rheumato
Rheumato, Vol. 5, Pages 8: Unlocking the Secrets of Knee Joint Unloading: A Systematic Review and Biomechanical Study of the Invasive and Non-Invasive Methods and Their Influence on Knee Joint Loading
Rheumato, Vol. 5, Pages 8: Unlocking the Secrets of Knee Joint Unloading: A Systematic Review and Biomechanical Study of the
The Lancet
[Comment] The brain as a window into rheumatoid arthritis stratified medicine?
TNF inhibitors have transformed outcomes for many, but not all, people with rheumatoid arthritis. Their approval in the late 1990s
Rheumatology
Biomarkers in juvenile idiopathic arthritis: towards precision diagnosis and personalized therapy?
Purpose to review Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, characterized by persistent joint
The Lancet
[Comment] Polymyalgia rheumatica: killing them softly
Polymyalgia rheumatica has long been neglected, especially when it comes to pharmaceutical development: but why? In 2025, polymyalgia rheumatica should
NEJM
Myasthenia Gravis — Redemption for B-Cell Depletion
Myasthenia gravis, an immune-mediated neurologic disorder, has for the past century been treated effectively with various immunotherapies, ranging from thymectomy
NEJM
Unruptured Intracranial Aneurysms
Intracranial aneurysms are common, and the risk of rupture is influenced by size, location, morphology, and factors such as hypertension,